Featured Head and Neck Cancer Clinical Trials

Collection of Blood and Tissue from Patients with Upper Aerodigestive Malignancies for Research Purposes (The UAM Tissue Resource) IRB 07-267 | HOSPITAL Main Campus | DISEASE Esophageal, GI (Gastrointestinal), Head and Neck, Lung, Lung – Mesothelioma, Lung – Pleural Mesothelioma, Thyroid

A Randomized Phase II Study of Adjuvant Concurrent Radiation and Chemotherapy versus Radiation Alone in Resected High – Risk Malignant Salivary Gland Tumors

IRB RTOG 1008 | CC CC00031 | HOSPITAL Main Campus | PHASE Phase 2 | DISEASE Head and Neck, Salivary Gland

Outcomes Registry of Patients with Head and Neck Cancer Undergoing Definitive Treatment at Cleveland Clinic

IRB CASE 4311 | CC CC00192 | HOSPITAL Main Campus | DISEASE Head and Neck

Randomized Phase II/III Trial of Adjuvant Radiation Therapy (RT) with Cisplatin, Docetaxel-Cetuximab, or Cisplatin-Atezolizumab in Pathologic High-Risk Squamous Cell Cancer of the Head and Neck

IRB RTOG 1216 | CC 13-420 | HOSPITAL Fairview, Hillcrest, Independence, Main Campus, Mansfield, North Coast Cancer, Parma, Strongsville, Wooster | DISEASE Head and Neck

Randomized Phase II and Phase III Studies of Individualized Treatment for Nasopharyngeal Carcinoma Based on Biomarker Epstein Barr Virus (EBV) Deoxyribonucleic Acid (DNA)

IRB NRG HN001 | CC 14-691 | HOSPITAL Beachwood, Fairview, Hillcrest, Independence, Main Campus, Mansfield, North Coast Cancer, Strongsville, Wooster | PHASE Phase 2, Phase 3 | DISEASE Head and Neck, Nasopharyngeal Carcinoma

Molecular Analysis for Therapy Choice (MATCH)

IRB EAY 131 | CC 15-890 | HOSPITAL Main Campus | DISEASE All Cancer Types, Lymphoma

Tissue and Body Fluid Analysis from Patients with Cancer and Other Risk- Associated Lesions

IRB CASE 11Z15 | CC 15-1580 | HOSPITAL Fairview, Hillcrest, Main Campus | DISEASE All Cancer Types

Identifying risk factors, biomarkers and outcomes of primary and recurrent cancer associated thrombosis

IRB CASE 15Z16 | CC 17-498 |HOSPITAL Main Campus | DISEASE All Cancer Types

Evaluating the Microbiome of Long-Term Childhood Cancer Survivors and the Relationship to Metabolic Syndrome

IRB CASE 4Z18 | CC 18-357 | HOSPITAL Main Campus | DISEASE All Cancer Types

Phase II Study of IMRT Re-Irradiation with concurrent/adjuvant Nivolumab in patients with locoregionally recurrent or second primary squamous cell cancer of the head and neck

IRB WCI 1318 | CC 18-1547 | HOSPITAL Main Campus | STAGE Recurrent/Relapsed | PHASE Phase 2 | DISEASE Head and Neck, Squamous Cell Carcinoma of H&N

A randomized Phase II study of re-irradiation of SBRT plus anti-PD-1 antibody Pembrolizumab (Keytruda®) versus SBRT Kalone for locoregionally recurrent or second primary head and neck carcinomathe head and neck

IRB RFI 1318 | CC 19-560 | HOSPITAL Main Campus | STAGE Recurrent/Relapsed | PHASE Phase 2 | DISEASE Head and Neck,

A Phase 3 Study of Pembrolizumab Versus Placebo Following Surgery and Radiation in Participants with High-risk Locally Advanced Squamous Cell Carcinoma of the Skin (KEYNOTE-630; MK-3475-630).

IRB MRK 1619 | CC 19-776 | HOSPITAL Main Campus | PHASE Phase 3 | DISEASE Head and Neck, Squamous Cell Carcinoma of H&N

A Phase III, Randomized, Controlled, Double-Blind Study Evaluating the Safety of Two Doses of Apixaban for Secondary Prevention of Cancer Related Venous Thrombosis in Subjects Who Have Completed at Least Six Months of Anticoagulation Therapy

IRB ACCRU 1Y19 | CC 19-058 | HOSPITAL Florida Weston, Main Campus | STAGE Stage 4 | PHASE Phase 3 | DISEASE All Cancer Types

Randomized Phase II/III Trial of Radiotherapy with Concurrent MEDI4736 (Durvalumab) vs. Radiotherapy with Concurrent Cetuximab in Patients with Locoregionally Advanced Head and Neck Cancer with a Contraindication to Cisplatin

IRB NRG HN004 | CC 19-1319 | HOSPITAL Main Campus, Mansfield, North Coast Cancer, Wooster | STAGE Advanced/Metastatic PHASE Phase 2, Phase 3 | DISEASE Head and Neck, Squamous Cell Carcinoma of H&N

A Phase III, Randomized, Double-Blind, Placebo-Controlled Trial to Investigate the Effect of a Perioperative Analgesia Protocol on Postoperative Opioid Usage and Pain Control in Patients Undergoing Major Head and Neck Cancer Surgery Requiring Microvascular Free Flap Reconstruction

IRB CASE 6319 | CC 19-1203 | HOSPITAL Main Campus | PHASE Phase 3 | DISEASE Head and Neck

Search our Head and Neck Clinical Trials Database for a full listing of all open and accruing studies.