August Featured Cancer Clinical Trials

BLADDER
A Phase II Trial of Pembrolizumab (MK-3475) in Subjets with Advanced / Unresectable or Metastatic Urothelial Cancer
MRK 2814 | 15-500
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BMT
Prospective Outcomes of Second-line Therapy in Acute Graft-versus-Host Study including ECP POSTAGE
VICC 1Z14 | 14-1484
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BRAIN
A Pilot Trial of Intraparenchymally-Administered Topotecan using Convection-Enhanced Delivery (CED) in Patients with Suspected Recurrent/Progressive WHO Grade III or IV (High Grade) Glioma Undergoing A Clinically-Indicated Surgical Resection (IND 117,240)
INFT 1315 | 15-614
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BREAST
A study of Neratinib Plus Capecitabine versus Lapatinib Plus Capecitabine in patients with HER2+ Metastatic Breast Cancer who have received two or more prior HER2-directed regimens in the metastatic setting (NALA)
PUMA 1113 | CC031421C
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LEUKEMIA, ACUTE MYELOID (AML)
A Phase 1/2 Open-Label, Dose Escalation Study Investigating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ASP2215 in Patients with Relapsed or Refractory Acute Myeloid Leukemia
APGD 1914 | 14-863
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LIVER
Multicenter Phase 1 b/2 Study of Tivozanib in Patients with Advanced Inoperable Hepatocellular Carcinoma
RPCI 1213 | 011419C
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LUNG
CLVS 2514 (Tiger 1) Protocol entitled: A Randomized, Open-Label, Phase II Study of CO-1686 or Erlotinib First-Line Treatment of Patients with EGFR-Mutant Advanced Non-Small Cell Lung Cancer (NSCLC)
CLVS 2514 | 15-019
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LYMPHOMA
A Phase 2b Open-label, Randomized Two-arm Study Comparing High and Low Doses of Selinexor (KPT-330) in Patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)
KARY 1414 | 14-1340
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MYELOMA
A phase 2, multicenter, single-arm, open-label study of pomalidomide in combination with low-dose dexamethasone in subjects with relapsed or refractory Multiple Myeloma following lenalidomide-based therapy in the second-line setting
CLGN 1A14 | 14-1374
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PROSTATE
Phase III Trial for Enzalutamide versus Enzalutamide, Abiraterone and Prednisone for castration resistant metastatic prostate cancer
A031201| 14-332
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SOLID TUMORS
A Phase 1, open-label study to evaluate the safety, tolerability, and pharmacokinetics of TAS-102 in patients with advanced solid tumors and varying degrees of renal impairment
TAHO 1Y15 | 031501C
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THROMBOCYTOPENIA, MYELOFIBROSIS
A Randomized Controlled Phase 3 Study of Oral Pacritinib versus Best Available Therapy in Patients with Thrombocytopenia and Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis
CTI 1Z14 | 14-954
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Search our Cancer Clinical Trials database for a full listing of all open and accruing studies: clevelandclinic.org/CancerClinicalTrials.