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Brexanolone injection may bring relief from postpartum depression within three days, though some questions remain

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The first ever medication indicated to treat moderate to severe postpartum depression by helping regulate the hormone levels that drop after childbirth has received FDA approval.

Designated a breakthrough therapy, FDA gave the medication, brexanolone injection, priority review. This is particularly timely as Ob/Gyns implement the new recommendations from the American College of Obstetricians and Gynecologists (ACOG) for earlier, and more frequent, postpartum care.

Sold by Sage Therapeutics, brexanolone injection is the first pharmacological therapy specifically indicated for postpartum depression. The medication works quickly—within a few days according to three company-sponsored clinical trials. Specifically, clinical trials found brexanolone injection led to clinically meaningful reductions in the Hamilton Rating Scale for Depression (HAM-D) score at 60 hours compared to the placebo.

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