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SearchResearchers develop first-of-its-kind neoantigen atlas to better understand immunotherapy resistance
Immunotherapy has come to the forefront of cancer treatment, yet an estimated half of all patients do not respond to this therapy. Researchers at Cleveland Clinic led a team in investigating this phenomenon. “Understanding why the immune system responds in some cases and not others is of great interest because this may help overcome resistance,” explains Tyler Alban, PhD, co-first author of the study and a computational biologist and faculty member at Cleveland Clinic.
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Patients who responded had a notable reduction in mutational burden after starting immunotherapy. However, the researchers were surprised to find that patients who did not respond to immunotherapy also had a neoantigen response. The study results, which were published in Nature Medicine, showed that in the latter cases, the immune system recognized subclonal neoantigens as opposed to responders who recognized clonal neoantigens. “These findings give us hope that if we can modify their antigen response, we might be able to get their immune system to better recognize [and attack the cancer cells],” says Alban.
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